Chitosan-alginate hydrogels for simultaneous and sustained releases of ciprofloxacin, amoxicillin and vancomycin for combination therapy

A set of chitosan-alginic acid hydrogels were prepared for multiple encapsulation and release antibiotics future application in combination therapy. Vancomycin, ciprofloxacin amoxicillin used as models, widely therapy, either individually combination. The by a simple, low cost solventfree approach based on complexation between chitosan alginic followed crosslinking with CaCl2 to enhance structural properties. loaded during the gelification process maximize efficiency, reduce loss material. All formulations analyzed scanning electron microscope investigate surface morphology, inner structure, effect drugs loading. swelling behavior, cytotoxicityand antibacterial activity, evaluated. investigation impact simultaneous loading along variation surrounding pH, trend, represents key part work. results revealed that physicochemical properties drugs-loaded play an essential role changes profile.